We performed analysis of a publicly available DNA microarray data on 120 RMS tumor specimens reported by Davicioni et al.27 and analyzed the data for c-myb expression, expression of myogenic regulatory factors: MyoD, myogenin, Myf5 and MRF4 (Myf 6), selected muscle-specific genes ACTN2, MYH8, TNNC2, CKM inhibited by c-Myb during myogenic differentiation of the C2C12 myoblast cell line9, and several other genes that are regulated by c-Myb, specifically: Slug28, cathepsin D, matrix metalloproteinases 1/929, Bcl-2, c-Kit, cyclinB1, CD34, mim113, CXCR430, and Myb-binding protein 1A. The gene discussed is CTSD; the disease is neoplasm.