Results obtained by Tripp et al. suggested an impaired excitation/inhibition balance in MDD potentially mediated by decreased GABA content; however, of relevance to this issue might be the results obtained recently, indicating a down-regulation of the SST levels in the anterior cingulate cortex, dorsolateral prefrontal cortex, and amygdala of MDD patients (Tripp et al. 2011; Sibille et al. 2011; Guilloux et al. 2012; Lin and Sibille 2015). Here, SST is linked to major depressive disorder.