For ovarian cancer, the prognostic significance of FoxP3+ Tregs varied based on disease stage, in high grade or advanced ovarian cancer, high numbers of FoxP3+ Tregs infiltrating were found to be associated with improved survival (OR 0.34, 95% CI 0.21 to 0.56, P < 0.001), whereas the pooled analysis of the remaining studies showed a poor prognostic effect of FoxP3+ Tregs (OR 2.29, 95% CI 1.07 to 4.90, P = 0.033) (Table 2). This evidence concerns the gene FOXP3 and ovarian cancer.