The final variation nominally associated with gout was CD14 SNP rs2569190. This SNP is in the 5’UTR of one of the two CD14 splice variants, with the minor allele (that increases risk of gout) increasing expression in monocytes by decreasing affinity for the inhibitory Sp3 transcription factor [42], enhancing the loading of RNA polymerase II [43] and is associated with increased soluble CD14 levels in healthy individuals [44, 45]. This evidence concerns the gene CD14 and gout.