The T allele of CARD8 rs2043211 (C10X) has been associated with increased risk of gout in Chinese [17], and rs2149356 in toll-like receptor 4 (TLR4), a receptor functionally implicated in MSU-stimulated inflammation [18], has also been associated with serum IL-1β levels and the risk of gout in Han Chinese [19]. Here, TLR4 is linked to gout.