Phosphorylation of K8 is reduced in tumour progression.36 The relative phosphorylation at sites pSer431, pSer23 and pSer73 in INACT, ACT and control tissues was therefore evaluated by western immunoblot and relative densitometry to an internal standard of MCF-7 IF extract (figure 2Cii, E). Here, KRT8 is linked to neoplasm.