KRT8 and inflammatory bowel disease: Alteration in K8 patterns occur around colorectal neoplasia4; polymerisation-inhibiting mutations in K8 were observed in a subset of inflammatory bowel disease (IBD) patients8; transgenic mice lacking K8 exhibit hyperplasia in the colon and impaired barrier and absorptive function in addition to developing colorectal neoplasia.9 The literature on associations between keratin expression, function and colorectal disease has recently been reviewed.7