In comparison to a control group of 135 individuals with no ultrasonographic evidence of fatty liver, the rs58542926 variant was found to be significantly associated with fatty liver (OR 1.37, CI 1.02 to 1.84); however, this relationship did not persist after adjusting for age, BMI and rs738409 in PNPLA3. The NAFLD group was subdivided into 96 patients with SS and 130 with NASH; the T allele was found to be associated with disease progression when the control group was included in the analysis; however, this was not significant when the SS group was compared with NASH. Here, PNPLA3 is linked to metabolic dysfunction-associated steatohepatitis.