The angiotensin II receptor 1, encode by AGTR1 on chromosome 3, is a receptor expressed in the liver by stellate cells that initiates a response to tissue injury.9, 75 Receptor activation is thought to promote profibrogenic cytokines including transforming growth factor β 1 (TGFB1) which may also have a role in lipid accumulation,76 and SERPINE1 inhibits enzymes involved in fibrinolysis.9 Variants in these genes have been investigated as potential risk factors for NAFLD susceptibility. The gene discussed is AGTR1; the disease is metabolic dysfunction-associated steatotic liver disease.