Therefore, to ensure that the use of this control group was not influential, the five variants (PNPLA3, NCAN, GCKR, LYLPAL1 and PPP1R3B) were compared between the NASH CRN cohort and 3212 healthy participants within the Illuminata Control Database (iCONT). Here, PNPLA3 is linked to metabolic dysfunction-associated steatohepatitis.