In total, 1536 SNPs were selected for further analysis and 11 SNPs were found to be associated with NAFLD, 7 of these in the SLC2A1 gene and 1 close to SLC2A1, and variants in CYP2E1, MTR and STK11. A validation study was then performed on a cohort of 451 European patients with NAFLD and 303 controls, and confirmed that rs4658 and rs841856 in SLC2A1 were significantly more frequent in the NAFLD group, however no association was seen in the other variants. Here, SLC2A1 is linked to metabolic dysfunction-associated steatotic liver disease.