The catalytic subunit of glutamate-cysteine ligase (GCLC) is involved in the synthesis of glutathione (GSH).9 GSH is a tripeptide that counteracts cellular oxidative stress from reactive metabolites through thiol group reduction.46 Oliveira et al40 evaluated the −129C/T GCLC polymorphism in a cohort of 139 Brazilian patients with NAFLD, 45 with SS and 86 with NASH. Here, GCLC is linked to metabolic dysfunction-associated steatohepatitis.