GCK and metabolic dysfunction-associated steatotic liver disease: GCKR encodes glucokinase regulator, a protein that modulates the activity of the enzyme glucokinase in liver cells by reversibly binding to form an inactive complex.9 Tan et al80 investigated the GCKR rs780094 (C>T) and rs1260326 (C>T) SNPs on a mixed ethnicity Malaysian cohort of 144 patients with NAFLD and 198 controls.