The Kruppel-like factor 6 encoded by KLF6 on chromosome 10 is a zinc finger transcription factor which functions as a tumour suppressor, and polymorphisms have been implicated in various cancer types.9 Miele et al67 investigated the Kruppel-like factor 6 rs37508611 IVSI-27 G>A polymorphism on two cohorts of 306 UK and 109 Italian patients with biopsy-proven NAFLD. Here, KLF6 is linked to neoplasm.