ME1 and Patent ductus arteriosus: Enzymes utilized for glutamine metabolism in PDA, GLS1, GOT1/2, and malic enzyme 1 (ME1) (see pathway, Fig. 1a), in addition to NQO1, were significantly upregulated in PDA compared to 17 other cancers when assessed using the Oncomine webtool (Fig. 1b) [8].