To determine whether pharmacologic inhibition of GLS1 in combination with ß-lap would lead to synergistic inhibition of PDA tumor growth in vivo, we utilized the clinical formulation of ß-lap (ARQ761), hydroxypropyl beta cyclodextrin travel (HPßCD)-ß-lap, and the orally available GLS1 inhibitor, CB-839, provided by Calithera Biosciences. The gene discussed is GLS; the disease is Patent ductus arteriosus.