The observation that immunoprecipitation of Bcl-xL and Bcl-2 family proteins from Bim-containing complexes was not altered by paclitaxel treatment further conforms the specificity of the Bim and Mcl-1 association, which is consistent with the finding that the Bim/Mcl-1 complex is critical for apoptosis modulation in chronic lymphocytic leukemia [41, 42]. This evidence concerns the gene BCL2 and B-cell chronic lymphocytic leukemia.