Our results showed that GIT1 protein levels were significantly elevated in A549, CL1–5, H520 and H1299 cells, and that the expression of GIT1 protein was positively correlated with migration and invasion in 6 human adenocarcinoma (AD) cell lines and 5 other lung cancer cell lines including squamous cell carcinoma (SCC) and large cell carcinoma (LCC) (Figure 2a). The gene discussed is GIT1; the disease is leukoencephalopathy with calcifications and cysts.