Finally, the improvement in eGFR in these studies may be at least in part dependent on a decrease in serum creatinine as a result of muscle loss related to coexisting comorbid illness or malnutrition [6–8], a phenomenon which seems unlikely in our cohort, as no reduced BMI or serum albumin was registered in CKD regressors. The gene discussed is ALB; the disease is nutritional deficiency disease.