The 8 SNPs (CD3EAP rs967591, TNFRSF10B rs1047266, AKT1 rs3803300, C3 rs2287845, HOMER2 rs1256428, GNB2L1 rs3756585, ADAMTSL3 rs11259927, and CD3D rs3181259) were found to be significantly associated with OS and/or DFS (Table 2 and S1 Fig) when adjusted for age, gender, smoking status, tumor histology, pathologic stage. The gene discussed is C3; the disease is neoplasm.