It seemed apparent that the clinical benefit of the selective EGFR-TKI (gefitinib, erlotinib) or the EGFR-specific MoAB (cetuximab) were limited in esophageal cancer, with reported ORR of 2.0%-6.6% and PFS of 1.6-1.8 months [8, 9, 15–18]. Here, EGFR is linked to esophageal cancer.