We now present in vitro data obtained in HepG2 and HuH-7 cell lines, as well as in vivo data from HCC xenografts in NOD/SCID mice, indicating that SI113 inhibits liver cancer cell proliferation, induces apoptosis and necrosis and potentiates the effects of radiotherapy, mimicking some of the effects of SGK1 knock-down. Here, SGK1 is linked to hepatocellular carcinoma.