However, in some breast cancer cells lines displaying low/undetectable levels of SGK1, and sensitive to Akt1 specific inhibitors, a marked phosphorylation of NDRG1 was detected, that was suppressed by Akt inhibitors, differently from resistant cells [23], suggesting that under certain conditions Akt can also phosphorylate SGK1 targets. This evidence concerns the gene AKT1 and breast cancer.