To determine if the observed YK-4-279 activity (Figures 3–7) can translate into improved survival of mice with EWS-FLI1 induced leukemia, the animals were allowed to live with erythroleukemia following treatment with daily 150 mg/kg YK-4-279 or vehicle IP injections, five times a week for two weeks in a repeat experiment. This evidence concerns the gene FLI1 and erythroleukemia.