Because TGF-β and hypoxia are the best characterized and most often used as inducers of EMT [6, 10], we first established a hypoxia-induced EMT model in three LAD cell lines (A549, NCI-H1650 and SPC-A1) to study the miR-214 function in the EMT. Here, TGFB1 is linked to leukocyte adhesion deficiency.