The highly deregulated genes, up-regulated (left column) and down-regulated (right column), in the TSP-1 deficient mice after AOM-DSS treatment are categorized according to molecular function/ontology, below. Numbers in brackets represent fold-change: first value refers to fold-change in the comparison between treated TSP-1-/- vs water-TSP-1-/-; second value refers to fold-change comparing treated TSP-1-/- vs treated WT, p<0.05). This evidence concerns the gene THBS1 and infectious otitis media.