In this work, by deciphering the overlapping genes, crosstalking genes and pivotal regulators of both UC- and CRC-associated functional module pairs, we revealed a variety of genes (including FOS and DUSP1, etc.), transcription factors (including SMAD3 and ETS1, etc.)and miRNAs (including miR-155 and miR-196b, etc.)that may have the potential to complete the connections between UC and CRC. The gene discussed is DUSP1; the disease is colorectal carcinoma.