Having confirmed the expression of these genes in PCa cells, we next determined the effects of ectopic over-expression of miR137 on the mRNA and protein levels of KDM1A, KDM2A, KDM2A, KDM5B, KDM7A, CBP, SUZ12, MED1 and NCoA2. We over-expressed miR137 and scrambled control non-targeting miRNA in PC3 cells which lack endogenous miR137 but which express the validated miR137 target KDM1A (Figure 2A). This evidence concerns the gene KDM1A and posterior cortical atrophy.