In this report we first sought to determine whether specific microRNAs, including miR137, which are expressed in normal prostate cells but lost in PCa cells, function as repressors of KDM1A. Our analysis revealed that miR137 targets an extended network of transcriptional coregulators, including KDM1A/LSD1/AOF1, KDM2A/JHDM1A/FBXL11, KDM4A/JMJD2A, KDM5B/JARID1B/PLU1, KDM7A/JHDM1D/PHF8, MED1/TRAP220/DRIP205 and NCoA2/SRC2/TIF2. Ectopic restoration of miR137 expression decreases expression of these transcriptional coregulators. The gene discussed is MED1; the disease is posterior cortical atrophy.