It was previously established that miR137 negatively regulates many genes implicated in cancer including the transcriptional coregulators KDM1A [4, 6, 45] and NCOA2 [13, 38], aurora kinase A (AURKA) [6], estrogen-related receptor ERRα/NR3B1 [12] and constitutive androstane receptor (CAR/NF1I3)[46], the CDC42 and CDK6 cell cycle regulators [7, 47], the ubiquitin ligase MIB1[48], COX2 [5], paxillin [49], chromosome segregation like-1 CSE1L gene [50], glioma pathogenesis-related protein 1 (also referred to as RTVP1) [51], the EZH2 polycomb protein [52] and CtBP1 [53]. The gene discussed is CDC42; the disease is cancer.