Our analysis inherently deals with this issue of relative time adjustment and shows that for most obesity and cardio-metabolic health markers (BMI, waist circumference, blood pressure, triglycerides, C—reactive protein, plasma insulin and HOMA) the composition of time spent in sleep, SB, LIPA and MVPA appears to matter as a whole. The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.