WRAP53 was first implicated in cancer in an extensive re-sequence analysis of TP53 and its flanking genes, where single nucleotide polymorphisms (SNPs; rs2287498 and rs2287499; in linkage disequilibrium) was suggested to be associated with increased risk for developing Estrogen Receptor (ER) negative breast carcinomas[6]. Here, TP53 is linked to breast carcinoma.