Recent years, accumulating studies have shown that CUL4A expresses abnormally in multiple cancers including breast cancer, squamous cell carcinoma, pleural mesothelioma [9-12], and one latest study found CUL4A overexpressed in non-small-cell lung cancer and stimulated the latter growth as well as tumorigenesis [13]. Here, CUL4A is linked to pleural mesothelioma.