And a recent study illustrated that CUL4A promoted H3K4me3 at the promoter of ZEB1 and then led to transcriptional upregulation of ZEB1 expression in breast cancer cells, and knockdown of ZEB1 blocked CUL4A-induced cell proliferation, EMT, tumorigenesis, and metastasis [14]. The gene discussed is ZEB1; the disease is breast carcinoma.