Thus, to examine whether mTORC1 inhibition could suppress MCL-1 expression in these DLBCL cell lines, we treated them with either BEZ235, MLN0128, or PIK-75 (a compound that suppresses MCL-1 transcription [42]) and measured MCL-1 levels over time by immunoblot. The gene discussed is MCL1; the disease is diffuse large B-cell lymphoma.