However, unlike other tumor cell contexts, where suppression of mTORC1 has been shown to reduce MCL-1 expression [10-12], our analysis of GCB-DLBCL cells reveals an unpredicted mechanism of synergy wherein suppression of AKT induces mitochondrial accumulation of BAD and BIM (Figure 8). This evidence concerns the gene AKT1 and diffuse large B-cell lymphoma.