We focused our investigation on the plant homeodomain (PHD)-containing protein PF1 (PHF12), which links SIN3 PAH2 to a chromatin-modifying protein complex containing MRG15, LID (the Drosophila homolog of KDM5A/B) and EMSY [20, 23-25] that has been implicated in breast cancer [26-30]. This evidence concerns the gene PROS1 and breast cancer.