mda-7/IL-24 displays multiple properties that support its ability to serve as a cancer suppressor gene, including an ability to selectively induce apoptosis and toxic authophagy in a broad-spectrum of cancer cells, potent “bystander” antitumor activity, anti-angiogenic activity, immune modulatory properties and synergy with conventional therapeutics (radiation, chemotherapy and antibody-based therapies) [rev. This evidence concerns the gene IL24 and cancer.