They demonstrated that human tumor cells expressing HLA-G grow in an immunocompetent host by affecting both innate and adaptive immunity through expansion of myeloid-derived suppressive cells, loss of peripheral T cells, and cytokinic balance in favor of Th2 (increased IL-4, IL-10, and IL-13) over Th1/Th17 cytokines. This evidence concerns the gene IL4 and neoplasm.