Another intriguing question raised by our data comes from the contrast between decreased TTL expression (and thus high levels of Detyr-tubulin) observed in aggressive mammary and prostate tumors [28, 70] and the high Tyr-tubulin levels found in paclitaxel-resistant MCF-7 breast cancer cells [29] and in our taxane-adapted cells (this study). Here, TTL is linked to breast cancer.