CXCL1 and neoplasm: Similarly, a2NTD treatment enhanced the expression of different chemokines, For instance; CXCL-1, CXCL-2 and IL-8, which are a potent neutrophil chemoattractants, CCL-2; a monocytes chemoattractant, suggesting that a2NTD programmed neutrophils might be a part of a paracrine network in the tumor site to insure a constant recruitment of neutrophils and monocytes to the site of the tumor, in order to promote tumor progression.