TAN promote angiogenesis and metastasis in tumors by secreting protumorigenic factors, for instance; IL-8 and VEGF, potent pro-angiogenic mediators as well as MMP-9 to degrade extracellular matrix, which promote tumor growth, angiogenesis and metastasis [9, 10, 27, 28]. This evidence concerns the gene CXCL8 and neoplasm.