Overall, the present study confirmed that pMFAP4 levels are markedly induced in liver fibrosis, which suggests applicability of MFAP4 as a novel non-invasive biomarker for assessment of hepatic fibrosis and identification of high-risk patients with severe fibrosis stages Larger studies are warranted for the validation hereof. The gene discussed is MFAP4; the disease is Hepatic fibrosis.