The tumors of patients with late-onset GC presented significantly higher SRC and LYN protein (by IHC and western blotting) and mRNA (by RT-qPCR) expression, as well as reduced CKB protein expression by western blotting, compared with early-onset CG samples (p < 0.05, for all comparisons; Table 2). The gene discussed is LYN; the disease is gastric cancer.