Together these findings demonstrate that the Tat peptides did not induce anxiety or depression-like behavior in the novelty-suppressed feeding and forced-swim tests; however, anxiolytic and antidepressant responses were markedly influenced by disruption of PKA complexes, in particular PKA/AKAP, but not the RACK1/NR2B complex. The gene discussed is GRIN2B; the disease is depressive disorder.