Interestingly, another AKAP-interacting signaling molecule, the protein phosphatase calcineurin,72 mediates the antidepressant effects of the serotonin reuptake inhibitor fluoxetine73 and serotonin and norepinephrine reuptake inhibitor venlafaxine.74 The multiprotein complexes scaffolded by AKAP might thus emerge as key mediators of depression-related behaviors and potential novel targets for antidepressant treatments. The gene discussed is AKAP1; the disease is major depressive disorder.