SF3B1 encodes splicing factor 3b subunit 1, a component of the RNA splicing machinery, and mutations in the gene have been found to underlie myelodysplastic syndromes that predispose to leukemia.40 Besides this, Sf3b1 was shown to be prominently involved in processes for adult neurogenesis. This evidence concerns the gene SF3B1 and myelodysplastic syndrome.