Interestingly, the International Schizophrenia Consortium reported two duplications at the ROBO1 locus in their 2008 study involving several thousand schizophrenia cases and healthy controls: one in a case subject and the other in a control subject (both overlapping exons).30 The ROBO1 gene encodes an integral membrane protein that functions in axon guidance and migration of neuronal precursor cell across the midline in the developing brain in rodents. The gene discussed is ROBO1; the disease is schizophrenia.