Finally, it is also possible that CDH13 deficiency may induce more extensive inhibitory dysfunction under conditions of environmental adversity, similar to its role as a cardioprotector under acute or chronic cardiac stress or its function in angiogenesis and tumor growth in a mouse model of mammary tumor.38, 78 Further studies will be necessary to disentangle the contribution of CDH13 under different environmental conditions in more detail. Here, CDH13 is linked to neoplasm.