Here, we systematically screened common missense variants with predicted damaging effects in the exon regions of 10 APOBEC core genes (APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3D, APOBEC3F, APOBEC3G, APOBEC3H, and APOBEC4) and conducted a case-control study including 1,200 cases and 1,253 controls to investigate the associations between these variants and lung cancer risk. The gene discussed is APOBEC3C; the disease is lung cancer.