ICAM1 and cancer: The combination prevented and inhibited cancer metastasis in the well-validated animal model in a dose-dependent manner (Figure 4) through its inhibition on cell hetero-adhesion between cancer and endothelia cells (Figure 2) The inhibition included down regulation by HAMPT of ICAM-1 and integrin expression (Figure 3), the cloak effect (Figure 2F) caused by activated platelets to protect CTCs from immune attack and facilitate CTCs adhesion to endothelial cells for their subsequent gemmating and invasion to the underlying stroma.