THBS1 and neoplasm: In addition to association of c-MET activation with tumour progression, previous studies demonstrated that the HGF/c-MET signalling pathway plays a role in angiogenesis and lymphangiogenesis by promoting the growth of endothelial cells, increasing the expression of pro-angiogenic mediators, such as vascular endothelial growth factor, and suppressing the activity of thrombospondin 1-a negative regulator of angiogenesis.