Considering that a considerable percentage of HNSCC over-express anti-apoptotic Bcl-2 proteins and that high levels of Bcl-2 correlates with resistance to platinum-based CHT and thus with a poor prognosis, Bcl-2 pathway has become an attractive target for investigating the potential therapeutic effects of new drugs [12, 13]. Here, BCL2 is linked to head and neck squamous cell carcinoma.