Finally, a multivariable stepwise logistic regression analysis revealed that, in model 1, making adjustments for traditional cardiovascular risk factors and established inflammatory cytokines, sex, age, smoking, hypertension, hypercholesterolemia, triglycerides, LDL-C, HsCRP and IL-6 levels were independent determinants of USP in T2D patients with ICAS. This evidence concerns the gene IL6 and familial isolated congenital asplenia.