TNFRSF11B and familial isolated congenital asplenia: In particular the median serum FGF23 was 67.7 (59.5–77.8) pg/mL in ICAS and 43.89 (37.5–50.4) pg/mL in controls (p < 0.001), the median serum HsCRP was 7.95 (6.48-9.55) mg/L in ICAS and 3.95 (2.34–5.31) mg/L in controls (p < 0.001), the median serum OPG was 4.84 (3.52–5.95) pmol/L in ICAS and 2.48 (1.69–3.35) pmol/L in controls (p < 0.001) and the median serum IL-6 was 62.3 (57.1–68.5) pg/mL in diabetic patients with ICAS and 39.1 (33.8–45.2) pg/mL in diabetic controls (p < 0.001) (Table 2).