When FGF23 and OPG were included in the multivariable analysis (model 2), FGF23 and OPG remained independently associated with USP in ICAS patients, and the majority of the conventional risk factors in model 1 persisted in being determinants of ICAS in model 2 (Table 5). This evidence concerns the gene FGF23 and familial isolated congenital asplenia.