SPARC and melanoma: Although these observations are similar to the previous ones in melanoma, and breast cancer, in which SPARC is required in extracellular matrix synthesis [21]; ANGPTL4 weakens cell-cell conjunctions by initiating integrin α5β1-mediated RAC/PAK signaling [22]; VCAM1 often alters cell adhesion as a cell surface sialoglycoprotein [23]; and ITGA1 mediates cell-collagen or cell-laminin adhesion [24, 25].