Through the analysis, we found that PD-1+ TILs were related to high tumor grade (G1–2 vs. G3) (pooled RR 0.63, 95 % CI 0.54–0.73), big tumor size (T1 vs. T2–4) (pooled RR 0.72, 95 % CI 0.62–0.82), positive lymph node (+ vs. −) (pooled RR 1.76, 95 % CI 1.50–2.07), negative hormone receptor (+ vs. −) (pooled RR 0.75, 95 % CI 0.66–0.84) and HER-2 status (+ vs. −) (pooled RR 1.53, 95 % CI 1.08–2.16). This evidence concerns the gene ERBB2 and neoplasm.