TOP2B2 peaks from untreated cells are associated with three genes (CNTN4, IMMP2L and SATB2) implicated in both autism and schizophrenia whilst TOP2B2 peaks from E2-treated cells are associated with five genes (CNTN4, IMMP2L, EPC, SMG6 and CACNA1C). The gene discussed is SMG6; the disease is autism.