(2013), who found that level of CXCL10 in the CSF correlated with progression to HAM/TSP [43], suggesting that CXCL10 might play a critical role in stimulating migration of HTLV-1 infected T cells in the transwell chamber and ultimately reflecting what happens in vivo, when T-cells migrate into the CNS. The gene discussed is CXCL10; the disease is tropical spastic paraparesis.