F10 and deep vein thrombosis: One of the new anticoagulants, rivaroxaban, a direct factor Xa inhibitor, has been approved in US for prevention of deep-vein thrombosis (DVT) and venous thromboembolism (VTE) in surgery and for prophylaxis of the risk of stroke in people with abnormal heart rhythm (non-valvular atrial fibrillation) at 2011, and for treatment of DVT and pulmonary embolism at 2012.