The CSK rs34933034, CSK rs1378942, PTPN22 rs2476601 (R620W) and PTPN22 rs33996649 (R263Q) genotypes distribution were in Hardy-Weinberg equilibrium (Table 2) and for these four SNPs the genotyping success in HSP patients and controls was greater than 98 %. The gene discussed is PTPN22; the disease is hereditary spastic paraplegia.