Since HSP is generally a benign and self-limited pathology in children and a more severe condition in adults [2], in our study we also assessed if potential differences in CSK rs34933034, CSK rs1378942, PTPN22 rs2476601 (R620W) and PTPN22 rs33996649 (R263Q) could exist in HSP patients stratified according to the age at disease onset. The gene discussed is PTPN22; the disease is hereditary spastic paraplegia.