However, further analysis within only controls showed an association (positive) of CASP8 -652 6 N del/del (P = 0.03) polymorphism with high-risk HPV infection (only among black Africans) and a weak association (positive) with abnormal cytology (P = 0.048) suggesting a susceptible role for this genotype in the development of pre-cancers but not in cervical cancer [41]. Here, CASP8 is linked to cancer.