Carriers of the haplotype 11133 (GG/GG/TT/GG/CC), especially having the C allele of Q297H, significantly displayed increment of AST (2.2 IU/L) and ALT (3.8 IU/L) and hazard for fatty liver formation (odds ratio 1.68) compared with control. The gene discussed is GPT; the disease is fatty liver disease.