Our findings suggested that the MTTP Q297H polymorphism, substitution of glutamine by histidine in the N-terminal β-barrel, may have conformational change leading to a functional consequence in binding activity with apo B. Since the C allele of Q297H was quite prevalent (40.3 %) in our population, it may play an important role in NAFLD formation. The gene discussed is MTTP; the disease is metabolic dysfunction-associated steatotic liver disease.