CTRP9 overexpression reduces myocardial infarct area and hypoxia-induced apoptosis of cardiac myocytes following myocardial ischemia/reperfusion in a AMPK signaling pathway dependent manner [20] and substantially reduces the neointimal formation by suppressing the vascular smooth muscle cell proliferation and the migration through the cAMP/PKA/ERK pathway [11]. Here, C1QTNF9 is linked to myocardial ischemia.