The three phases of metabolic switch phenotype described above depend on a multitude of factors including the nature of oncogenic drive (e.g., c-myc or MET or PI3K mutations), organ site (breast or liver or brain) and the overall physiological status (e.g., diabetes, obesity etc.,) of the individual [41,42] Warburg’s original idea that aerobic glycolysis in cancer cells stems from irreversible mitochondrial respiration injury has not been found to be applicable in all the cancers. The gene discussed is MET; the disease is cancer.