The three phases of metabolic switch phenotype described above depend on a multitude of factors including the nature of oncogenic drive (e.g., c-myc or MET or PI3K mutations), organ site (breast or liver or brain) and the overall physiological status (e.g., diabetes, obesity etc.,) of the individual [41,42] Warburg’s original idea that aerobic glycolysis in cancer cells stems from irreversible mitochondrial respiration injury has not been found to be applicable in all the cancers. Here, MYC is linked to cancer.