Colonic CCL25 levels in mice with severe colitis, defined by persistent, severe diarrhea and wasting, increased more than 60-fold (P < 0.01), compared to presymptomatic mdr1a−/− mice, and were more than 350-fold higher than in wild-type mice (P < 0.05; Figure 3(b)). The gene discussed is CCL25; the disease is colitis.