Although mechanisms involved in the resveratrol-induced anti-proliferation of cancers are not fully understood, recently, we have shown that resveratrol induces anti-proliferation via integrin αvβ3 [34] binding site to activate ERK1/2, to induce nuclear accumulated cyclooxygenase-2 (COX-2) and p53-dependent mechanism in breast cancer, glioma, head and neck squamous cell cancer and ovarian cancer cells [29, 30, 35, 36]. Here, PTGS2 is linked to central nervous system cancer.